Research Guide · AA-NAD-2026-01N
NAD+
Nicotinamide Adenine Dinucleotide (Oxidized Coenzyme)
CAS
53-84-9
Mol. Weight
663.4 g/mol
Purity
99.93%
Format
500mg Vial
Overview
NAD+ (nicotinamide adenine dinucleotide) is a ubiquitous coenzyme present in every living cell, central to redox metabolism and mitochondrial energy production. Unlike the peptide compounds in this catalog, it is a small-molecule dinucleotide — and one of the most intensively studied molecules in longevity and cellular-metabolism research.
Mechanism of Action
NAD+ shuttles electrons through oxidative phosphorylation and serves as the obligate cosubstrate for sirtuins (SIRT1–7) and PARP enzymes, directly coupling cellular energy status to gene-expression regulation and DNA-repair pathways. Published literature documents a steady decline of tissue NAD+ levels with age, making restoration kinetics a major focus of metabolic research.
Dosing-Study Summary
Ageing-biology literature review
N/A — review of cellular & rodent models
Comprehensive mapping of NAD+ biosynthesis, consumption, and age-related decline pathways (PubMed #33353981)
Sirtuin-pathway mechanistic review
N/A — mechanistic review
Established NAD+ as the required cosubstrate linking sirtuin deacetylase activity to metabolic state (PubMed #24786309)
Rodent NAD+-repletion models
Precursor-supplemented, chronic dosing
Restored tissue NAD+ levels associated with improved mitochondrial and metabolic markers in published series
Doses shown are reported in cited preclinical / clinical literature for research reference only — not usage recommendations.
Storage & Handling
Store lyophilized at -20°C protected from light and moisture. Reconstitute with bacteriostatic water under sterile technique; refrigerate at 2–8°C and use promptly — NAD+ solutions are hydrolysis-sensitive. Avoid repeated freeze-thaw cycles.
Citations
This guide summarizes published scientific literature for laboratory research reference. Alpha Amino compounds are for research use only — not for human or animal consumption. Nothing here constitutes medical or dosing advice.