Research Guide · AA-GHK-2026-01Z
GHK-Cu
Copper Tripeptide-1 Complex
CAS
49557-75-7
Mol. Weight
404.9 g/mol
Purity
99.96%
Format
50mg Vial
Overview
GHK-Cu is a naturally occurring copper-binding tripeptide first isolated from human plasma, where its concentration declines measurably with age. Its research literature centers on extracellular matrix biology and gene-expression modulation.
Mechanism of Action
The GHK sequence chelates Cu²⁺ ions and delivers them into cells, where the complex modulates thousands of genes in transcriptomic studies — notably upregulating collagen, decorin, and antioxidant pathways while suppressing inflammatory signaling.
Dosing-Study Summary
Human fibroblast cell culture
Nanomolar range
Upregulated collagen and glycosaminoglycan synthesis markers (PubMed #25869516)
Rodent wound models
Topical application
Accelerated wound closure with improved matrix organization and antioxidant enzyme expression
Doses shown are reported in cited preclinical / clinical literature for research reference only — not usage recommendations.
Storage & Handling
Store lyophilized at -20°C. The copper complex is light-sensitive — amber handling or foil wrap recommended. Reconstitute with bacteriostatic water; solution appears pale blue when properly dissolved. Refrigerate at 2–8°C.
Citations
This guide summarizes published scientific literature for laboratory research reference. Alpha Amino compounds are for research use only — not for human or animal consumption. Nothing here constitutes medical or dosing advice.